Literally nothing matters until a human stands up and proclaims it matters to them. This show boating about "why does it matter? It doesn't matter to me!" Is antithetical to where things get "meaning" in the first place, i.e. subjectively.
Maybe I worded it wrongly, sorry. I didn't mean "why does it matter?" as if people shouldn't care about those questions. It was rather a rhetorical question, to show that the "simulation" might not depend on anything "outside the simulation", so the questions would simply make no sense.
Then again, this was just one of many variants of the simulation hypothesis, just something unfalsifiable that shouldn't be taken too seriously. :-)
In short, if it matters to me, it matters.