The only real theme is that we haven’t bought any companies yet to get the company. It’s always been because we have a lot of respect for the people involved.
So basically, if you care about what your startup is trying to accomplish, don't sell to Facebook.
And from what I've heard, if you care about your investors you shouldn't either. Supposedly some of the deals have been structured such that only the founders get compensated. Essentially large signing bonuses.
Given Facebook essentially just creates a single product on a fairly unique platform there seems to be little chance that anything would really be directly integrated into there product.
I can see acquisitions in future that may be more centered around removing competition such as something like foursqaure if they rendered Facebook places relatively unused and possibly events type startups to push their events platform more.
So basically, if you care about what your startup is trying to accomplish, don't sell to Facebook.