My own experience is that entrepreneurship is an obsession and an addiction. It is a character flaw. It is the deep desire to create and destroy at the same time. It is worse that a disease because disease at least has a curl, or the potential for a curl. The following are my recent articles on how to accept such a predicament and deal with setback and rejection, and how to recover from them.
http://foundread.com/2008/04/18/why-you-must-embrace-rejecti...
http://www.lovemytool.com/blog/2007/10/riding-a-bike.html