In addition to the MacBook Air and normal non-4K external display, it seems that this will also affect projectors. Therefore, it seems that presentation using macOS Mojave will only make your slides/keynote look bad and less professional. Moreover, the projector is not something you can upgrade. It is usually preinstalled in whatever venue where you give your presentation, and totally outside your control.
Many projectors don't use RGB striped subpixel grids anyway. They use color wheels or multiple chips to achieve full coverage, and in that case you want grayscale antialiasing.
And on top of usually not using RGB stripes, they also often use software keystone correction, which means that you don't know the native pixel grid anyway.
So there's no disadvantage for projectors, not at all.