I feel so grateful that my first GUI toolkit is Cocoa touch which is mature in design. At least the typing just works and object ownership is well defined.
I had not heard of enlightenment, so took a peek but as far as I could make out from the docs, it is linux/unix project? I saw nothing about MacOS or Windows... did I miss it?
[Py]Qt of course is cross-platform with the local look/feel.
In particular: https://github.com/DaveMDS/egitu
https://phab.enlightenment.org/w/projects/python_bindings_fo...
Scroll down to "python projects using EFL".