PICO-8 (and I assume, TIC-80 as well) are actually great for prototyping bigger game development projects - specifically due to its harsh constraints, which force a limited scope and sharp focus on the design.
I'm actually in the process of making SlipWays, a fast-paced 4X game for PC that started as a PICO-8 prototype (https://krajzeg.itch.io/slipways). A major reason for the tight game design of the game were the tight confines on the console.
I love SlipWays! It's really impressive that you crammed a game that deep into such a small system. That and Celeste were big inspirations to look into PICO-8 myself. Looking forward to the full release.
I'm actually in the process of making SlipWays, a fast-paced 4X game for PC that started as a PICO-8 prototype (https://krajzeg.itch.io/slipways). A major reason for the tight game design of the game were the tight confines on the console.