When my business first made $2k profit two months in a row (late March 2009), I did some math in my project notebook and wrote down a thought I had literally never had before: "Could quit the day job!?!" It took almost twelve months to the day from there.
$2k is plenty for a thrifty, healthy single, but what about kids or health insurance or retirement money? I guess ideally $2k is just a starting point.