Wire drains the battery of your phone so hard it's unusable in practice. There has been a bug report about this open since May 2017, with a note that "we're working on it". It hasn't been solved so far.
The last time i tried Wire its UX was about as stable as what a 12 year old would cobble together with old ducktape and string. Constantly exhibiting glitches and bugs and lacking even the most basic UI amenities as well as being a heavyweight browser app.
Does Wire have a light-weight and solid desktop client yet?
Wire [1] already has both end-to-end encryption and cross device sync. It's not the only one to do that either.
It's not a tradeoff.
[1]: https://en.m.wikipedia.org/wiki/Wire_(software)