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I'm not a big fan of Fortran for my particular domain, which includes lots of strings (biological sequences). Here Fortran is not as quick. See for example the k-nucleotide benchmark:

https://benchmarksgame.alioth.debian.org/u64q/performance.ph...



I worked with a customer that was using .NET for DNA sequencing.

Not sure what tricks they pulled off regarding unsafe code and parallelism, but it was fully done in C#.




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