You can actually. If you use mandoc instead of mandb, it automatically generates and passes tag files to less. Then you can just type ":t e" to jump to the docs for the -e option, for example.
A more realistic example might be that you're changing $LANG and now something broke. You can thus search for everything that uses LANG[1] and see what's most likely to have broken in what way.
There are some many things that are affected by locale environment variables (most of the time without documenting it explicitly), that this particular query is mostly useless.
> Search for manuals in the library section mentioning both the “optind” and the “optarg” variables:
> $ apropos -s 3 Va=optind -a Va=optarg
[1] https://man.openbsd.org/whatis.1