I can see python being very useful for this, but perhaps ruby would be a better fit? I can't help but wonder if lively.next+ruby on the truffle vm might not be able to steal a lot of attention, and kick off a bit of an "old-style" / message-passing object oriented revival... One can hope...
On The other hand, zope/zodb did manage to get pretty far wrt "magically persistent" object graphs for python.