I think it starts even sooner than that, with the confusion of abstractions and reality. Ralph Waldo Emerson described it in "Blight". Another thing that comes to mind is comparing "using science for this stuff" with a drunkard searching for a key near a lamp post because it's dark everywhere else, even though he knows for a fact that's the one spot it's not located. We're already restricting human thought to abstractions more and more, the asylum is already being run by the insane, so I think we're going to meet whatever we'll cook up more than half way comfortably.