One thing you might try is to start by writing some small CGI webapps/scripts. Later on, it will give you an appreciation of what the frameworks are actually doing for you.
Also, if you're not married to Python, and are looking for something really simple and easy to learn, you might try Perl's CGI::Application (along with some plug-ins).
Also, if you're not married to Python, and are looking for something really simple and easy to learn, you might try Perl's CGI::Application (along with some plug-ins).