I guess I'm alone in this, but I find page and window layouts built around a strict grid really strange looking. They look blocky and mechanical; full of rivers of space not unlike like poorly typeset text.
I find that space can help move the eye and accent parts of a layout. The grid and blocking are important, but at the same time they're also something to deviate from.
I find that space can help move the eye and accent parts of a layout. The grid and blocking are important, but at the same time they're also something to deviate from.