what you describe just shows that the old business model - pill in exchange for money - starts to show its limitations in the globalized world. Facebook would never get where it is now if it charged $10/year in Africa and $100/year in US. The pharma company who figures out that new business model would become that trillion dollar company.
There is no new business model that will derive a lot more money. There's a finite amount of global income available in a given year and it's not expanding at a rapid clip.
The very specific problem is the rest of the world will never pay it, and the US is aiming to stop paying it (exorbitant prices). Nothing is going to change that, it's a fact of life when resources such as income and wealth are inherently limited and expand fairly slowly overall. If you come up with something spectacular that is very valuable, they're still not going to pay it - it was demonstrated overwhelmingly by the HepC cure (and has been demonstrated by vaccines as another for decades; what's more life saving than vaccinations? and yet the developing world simply will not - and frequently can't - pay high prices for such).
Vaccines have saved hundreds of millions of lives. Give me an example of something that is going to beat that. Now take a look at the extraordinarily unspectacular financial outcome for the vaccination market (particularly compared to the trillion dollar premise being discussed). Why would anyone by default believe something amazing that comes out of CRISPR, would produce a dramatically superior financial outcome versus what vaccines have produced?
Perhaps I am up too late and don't completely understand where your question is coming from... but there's a lot of hope available in biology because DNA is one of the most successfully widely deployed technologies of the last 4 billion years. It's had hundreds of trillions of years being battletested in production environments. It's cheap to copy, replicate and eventually it will be cheap to modify and write. Literally everyone is (badly?) programmed with DNA-- and CRISPR isn't the last word on genome engineering. There will absolutely be changes that large chunks of the population will demand, far and beyond the demand for vaccines.
