The best protection against malware / ransomware, hardware failures or stupid accidents of your own doing is provided by regular backups, not by app store restrictions that don't work anyway for the stated purpose.
I do not have SELinux/AppArmor installed, I can't remember the last time I installed an antivirus and it doesn't matter, because I have backups with file versioning going back for a whole year of everything important.
My laptop could burn in a fire right now and I wouldn't lose anything.
But then I don't remember the last time I had problems with malware, because I don't install random software from shady internet sources either.
It's typical of software developers to solve social problems by automation instead of education. It doesn't work well, it never did.
All my UNIX-like OSes are locked down as much as I can, and yes I do enable SELinux, AppArmor, seccomp, Gatekeeper, SPI and friends.