and this more recently, 'Pesticides: an update of human exposure and toxicity'
" A huge body of evidence exists on the possible role of pesticide exposures in the elevated incidence of human diseases such as cancers, Alzheimer, Parkinson, amyotrophic lateral sclerosis, asthma, bronchitis, infertility, birth defects, attention deficit hyperactivity disorder, autism, diabetes, and obesity. Most of the disorders are induced by insecticides and herbicides most notably organophosphorus, organochlorines, phenoxyacetic acids, and triazine compounds."
"
In summary, young children may be
especially vulnerable to pesticides because
of the sensitivity of their developing organ
systems combined with a limited ability to
enzymatically detoxify these chemicals
(13,123,126-131). According to the
National Academy of Sciences (13), children's
OP exposures are of special concern
because "exposure to neurotoxic compounds
at levels believed to be safe for
adults could result in permanent loss of
brain function if it occurred during the
prenatal and early childhood period of
brain development" (13). Because there is
so little information available on the levels
and routes of children's pesticide exposure,
it is not feasible to conduct a risk assessment
predicting the likelihood of adverse
effects based on animal studies. Thus far,
there are no data in children to support or
refute the hypothesized health effects of
chronic low-level pesticide exposure."
"We conclude that PT and PO are genotoxic, while DF shows mitogenic activity. An important finding of this study is that PT had higher genotoxic potential than PO, which warrants for further investigations to correctly evaluate the hazards of exposure to these chemicals."
"Collectively, our results implicate gluconeogenesis as the key mechanism behind organophosphate-induced hyperglycemia, mediated by the organophosphate-degrading potential of gut microbiota. This study reveals the gut microbiome-mediated diabetogenic nature of organophosphates and hence that the usage of these insecticides should be reconsidered."
http://www.independent.co.uk/environment/environment-report-...