I'm not sure why the off-centre keyboard is a deal breaker.
I use a Microsoft semi-split ergonomic keyboard, and a Razer Naga mouse (heaps of bindings for dev stuff). Prior to getting the ergonomic keyboard (and a decent mouse) I had pretty extreme RSI.
However, if I look at my keyboard setup right now, whilst the keyboard as a whole looks fairly centred, ever so slightly to my left due to the mouse. The keys I actually type on (i.e. not the arrow keys or numpad) are all farther off centre, to my left. I'd assume this to be the case for most devs, excluding perhaps vi/emacs aficionados whom don't ever use their mouse.
It's hard to tell without touching the laptop, but I doubt having the keyboard off centre is going to cause problems. If anything I find using the trackpad on my Macbook below the keyboard gives me extreme RSI pain (I don't do it except when travelling).
The price tag is fairly extreme, but it's roughly on par with a high-end Macbook Pro (which many devs, including myself, use), however unlike a Macbook Pro it has the hardware to back-up the price tag.
My 15" rMBP was "only" $3k. The Razer is 50% more! It's a 2012 and still doing great. The Razer is closer to desktop performance, but that also means the battery life is abysmal.
True, my top-end rMBP from Late 2013 was around the same price and still doing reasonably well.
However, the current top-end rMBP is $4,299.00, whilst the top-end Razer Blade Pro is $4499.99. They're certainly both in the same (insanely expensive) ballpark, with the Razer Blade Pro having:
* a significantly higher resolution display
* twice the RAM
* a touch display
* a higher resolution webcam
* a significantly better GPU.
In favour of the rMBP:
* 15", instead of 17" (although that's my personal preference)
* Faster CPU (I think, I'm not up to date on which model beats which)
I'm by no means suggesting go out and buy a Razer Blade Pro. Just that, whilst expensive, it's no worse value for money than other high-end market laptops that are presently available.
Not only it is off-center but those mechanical switches seem to have attracted quite a lot of criticism.
To me a low-quality keyboard is a deal breaker, much more so than a less-than-perfect trackpad, because if you don't like the trackpad you can always carry a small, portable mouse while if you don't like the keyboard you don't really have a solution.
Being left-handed the off-center keyboard is also a bit right-handed for me. I have no use for a number pad on the right of the keyboard either. I just prefer Chromebook keyboards now, i.e. chicklet, centered and with no funny keys for Windows things or weird Apple keys that should be the right mouse button.
