It can work without in the sense that you can export an html file and open that in the browser. But there is no 'real' OpenGL support (yet?).
However, it's parent project vaex:
http://vaex.astro.rug.nl/
Does do this, but the volume rendering code needs cleanup, and it does not have an api like this package has.
But it would be possible, the shaders are almost the same, the techniques are, but I'm not sure if it is worth the effort. So by question back is, why would you want that?
