On: MacBook Pro

[jonknee]

Not if you have dozens of years of muscle memory for it being all the way to the top left. And since it's not a button you can't go by feel.

[wlesieutre → jonknee]

I would guess the margin on the left is still in the touch area for esc. If you've used the split keyboard on an iPad, they went as far as to include invisible key duplicates for the keys at the edges. The ones on the border are actually usable on either the left or right half.