>You'd find a huge sampling error because of epigenetics.
I'm skeptical that, just now that we know of epigenetic effects, they will invalidate all previously existing roughly-Mendelian genetics. It's not like people's eyes change from brown to blue if they're stressed in childhood.
So, you wouldn't necessarily find huge sampling error, you'd find sampling error proportionate to the epigenetic effect on that particular gene. Is that large? I suspect not for many genes we'd be interested in.
>Does it matter that I might have special tolerance genes which protect my brain lead fumes?
I don't think this is how epigenetic effects work.
I'm skeptical that, just now that we know of epigenetic effects, they will invalidate all previously existing roughly-Mendelian genetics. It's not like people's eyes change from brown to blue if they're stressed in childhood.
So, you wouldn't necessarily find huge sampling error, you'd find sampling error proportionate to the epigenetic effect on that particular gene. Is that large? I suspect not for many genes we'd be interested in.
>Does it matter that I might have special tolerance genes which protect my brain lead fumes?
I don't think this is how epigenetic effects work.