The essay "Shakespeare in the Bush" describes an anthropologist recounting "Hamlet" to a group of people in West Africa. Their cultural expectations completely upset her understanding of the "true meaning" of the play.
James Thurber wrote a short story for The New Yorker [1] where a fan of whodunnits picks up a copy of Macbeth and proceeds to read it while looking to solve who the real murderer of Duncan was (not Macbeth, too obvious).
http://www.naturalhistorymag.com/picks-from-the-past/12476/s...