Will the site redirect to AD network? If so, it is still easily blockable. AdBlocker can preload suspicious links and if they redirect to siteOfAdNetwork.com block them.
The only option I see here is to have some kind of click counter both on the web-master's (who monetizes) and client's (who advertises) web-sites. And the counters' numbers will be sent (using server-side) to the AD Network. But that doesn't work if the client wants to advertise not his/her web-side (where AD network's script can be installed) but Facebook profile or something like that.
Alternatively, AD network can charge not for number of clicks but for alternative parameters (e.g., number of days AD is published). Though, still not easy (no guarantees) to check whether web-master who's monetizing his/her web-site doesn't cheat.
The only option I see here is to have some kind of click counter both on the web-master's (who monetizes) and client's (who advertises) web-sites. And the counters' numbers will be sent (using server-side) to the AD Network. But that doesn't work if the client wants to advertise not his/her web-side (where AD network's script can be installed) but Facebook profile or something like that.
Alternatively, AD network can charge not for number of clicks but for alternative parameters (e.g., number of days AD is published). Though, still not easy (no guarantees) to check whether web-master who's monetizing his/her web-site doesn't cheat.