Depends on how much of the increase. If it's small increment, businesses have factored that in. If it's more than expected, then opportunity cost would increase thus making it harder to get money. http://ig.ft.com/sites/when-rates-rise/#faq-are-businesses-r...
I've invested in over 100 startups. Here's how it will change MY investing: not at all. If the rate kept rising and rising I might shift some startup dollars to bonds or whatever (if the return beat 7%).
