You should listen what people have to say when they describe it as a "Love Bomb", as "Seeing God", etc -- sometimes a little less quantifying can go very far in resolving problems physical or otherwise; the trick is experience and an open mind. The testimonials describing these substances as powerful healing tools is endless -- there is validity in this fact.
A single trip report could be worth a thousand peer reviewed papers, and a thousand trip reports could create a new science -- if you're willing to listen.
Not everything needs to be objectively verified in order to be agreed upon as useful or valid. Sometimes objective validation comes, by necessity, later.
I would recommend watching this documentary from Alejandro Jodorowsky's son, Christobol. Its important to watch it all the way through. In it he discusses Psychomagic and Psychoshamanism (two fields his father developed) and the relationship between ritual and healing, and how belief plays into the psychological or subconscious mechanism that promotes recovery. That's all I meant by my obviously rhetorical comments above, that there is an enormous amount of power within the belief centers of being.