> Of the 2909 participants in the intention-to-treat population, 1935 received enlicitide and 969 received placebo (5 did not receive enlicitide or placebo). The mean age of the participants was 63 years, and 39.3% were women. The mean (±SD) LDL cholesterol level at baseline was 96.1±38.9 mg per deciliter. The mean percent change in LDL cholesterol levels at week 24 was −57.1% (95% confidence interval [CI], −61.8 to −52.5) with enlicitide and 3.0% (95% CI, 0.9 to 5.1) with placebo, representing an adjusted between-group difference of −55.8 percentage points (95% CI, −60.9 to −50.7; P<0.001). The mean percent change in LDL cholesterol level at week 52, the mean percent changes in non-HDL cholesterol and apolipoprotein B levels at week 24, and the percent change in lipoprotein(a) levels at week 24 were significantly greater with enlicitide than with placebo (P<0.001 for all comparisons). The incidence of adverse events did not appear to differ between the groups.
"Phase 1 clinical trials of a 15-PGDH inhibitor for muscle weakness have shown that it is safe and active in healthy volunteers. Our hope is that a similar trial will be launched soon to test its effect in cartilage regeneration" - Helen Blau, Baxter Laboratory for Stem Cell Biology & the Donald E. and Delia B. Baxter Foundation Professorship
ERa activation promotes PGE2 resulting in decreased 15-PGDH.
So this is one of those standard poor estrogen signaling downstream things and simply improving the estrogen signaling and you get improved cartilage. Anyone can do this today along with getting all of the other positive effects. Those with EDS who have say variants on their TNXA/B have poor production ability to start and so we do everything we can to improve their cartilage production as they can only make so much which include doing stuff like this.
It depends on the person and their genetics. The further you get from the ERa the more complicated this gets and simply stating "Do X" wouldn't apply to everyone even if there are some incredibly common things to do. I might know all the upstream genes, their interactions, and symptoms by heart so it is pretty easy to identify, but general advice would go something like: eat well, get sleep and exercise.
I've read that specific type of exercise (repeating cycles of low impact move, cycling, rowing, elliptical machine) are the most effective at triggering cartilage growth. Is that accurate?
Because paywall I'm unable to open the paper, but do they ever specify the structure of the small molecule itself? In the associated non-paper materials (news pieces etc.) isn't identified beyond the name they gave it, PGDHi.
Getting vibes like a compsci paper that describes all about what an algo does but hides the sourcecode itself.
~1500 people disagree with you and some of them bought both books ($99 and $250).
Yes, a lot of online tutorial and snippets. No argument here. Not a lot of material to build a complete project. The value is in "Fractured" vs "Whole" knowledge tree.
Similar story here. We traveled with my wife for 3.5 years. Then we built homestead on 30 acres of forest land in rural WA. Now I am 36 and we bought land in HI to build our second homestead. And it is from scratch again! Most of our income comes from freelance gigs. The last time I visited big city was over 10 years ago. No regrets here.
I think the best framework is to not compare yourself to others. And fear of change is a normal, ordinary feeling. Comparing to others makes no sense, just try to do things that YOU will not regret and things that make you happy in long term.
Home schooling was a requirement for us. Having a social pool has never been a problem, as our kids learn to make friends really quickly and continue to keep in contact via g-chat and email once we part ways. Living like this, you tend to find lots of others in a similar lifestyle, so the kids are all very well adapted.
No kids for now but we are making plans. My wife is younger than me and we are planning to have kids in the next 1-2 years. Before we have kids we will decide and settle in one place. We will probably keep our second homestead since we are emotionally attached to it.
Love to hear any thoughts you have on homesteading in Washington state. Specifically, areas you think are good.
For some reason I am attracted to the south-eastern area that is drier. Forests say "fire" to me (and I also love the sun too much to be "enclosed" by a forest).
Yes, we are North-East, not far from Canadian border. A lot of snow, cold winters. We haven't lived in SE WA but visited the area you mentioned 3-4 times. The area between Pullman and, say, Kennewick. Way fewer trees, lower altitude but winters are less cold and less snowy. I would say there is no perfect place. Once you checked your main checkboxes, paradise is a state of mind, not place itself. You will have hot summers. We are at higher altitude, I have tractor primarily for snow but summers are much cooler. And we like cooler summers. This June was mostly at 68-75F, our german shepherd and I love it. I talked to a person from Texas and he mentioned 90-95F in May and 95-100F in June - no, thank you very much. We even bought land in HI at 3000 ft elevation to have 75F in summer and 72F in winter for the same reason.
South-East WA will have hotter summers, no shade from trees and every time we visited it was windy. having said that rolling hills are beautiful, farmers are nice, some healthy rivers for fishing. Pullman and Moscow have shopping and amenities.
No evidence for this particular case but can investors or competitors just gain private information about a company by pretending to buy it? It's free and the info is very detailed.
Only thing that will change Putin's mind is his defeat on the battlefield, period. Definitely, not sanctions. He will only stop if stopped by force. Sanctions only affect a very small fraction of Russia's population, so called quasi-middle class. Putin and rich oligarchs have more than enough, the poor majority is not affected.
Why not help Ukraine with jets and anti-air and solve Putin's problem now? It's obvious that corporate US thinks it is less profitable for them to escalate. It's more profitable to let Putin destroy an entire democratic nation. The short-term thinking and greed will backfire eventually. What does the West think Putin, disconnected from reality, power-drunk primate with a grenade in his hand, will do after Ukraine? Stay peaceful?
In 2014 Putin annexed Crimea, there was no reaction from the West. Nil, not even one serious sanction. Corporate interest decided to kick the can down the road.
The year is 2022, the West decides to kick the can down the road again. Corporations blame inflation on Putin meanwhile extracting record-high profits. Win-win, in the short term. There is no cure for human nature, in this case - greed.
And nuclear war argument is fear mongering by corporate media. Breaking Putin's army in Ukraine prevents further escalation. Because Putin has no army to invade other countries and makes it easier for Russian people to replace him with someone more sane.
> The safety data break down like this: 425 out of 1029 patients, or 41.3%, on the 10mg/kg Aduhelm dose experienced ARIA. Serious cases cropped up in 14 of those patients, the JAMA analysis shows. ARIA-edema (ARIA-E), or swelling, was the most common side effect seen in the pooled data, affecting 362 patients, or some 35%. ARIA-microhemorrhage, also known as microbleed, and ARIA-superficial siderosis, which is a type of slow brain bleeding, was observed in 19.1% and 14.7% of patients, respectively.
> Ninety-four (26%) of the 362 patients with ARIA-E experienced symptoms, most commonly headache, confusion, dizziness and nausea, the analysis shows.
> Swelling or bleeding were mild to moderate in those patients, but scans did show severe side effects in 12.2% of patients with swelling, 11.7% in patients with microbleeds and 21.9% in patients with slow brain bleeding.
