I have to chime in here. The full text is paywalled but if you have a subscription or institutional access the devil is in the details.
The "pilot study" the authors performed was an n=20 with 30% dropout, meaning 14 finished the study, 6/10 in the non-semaglutide arm and 8/10 in the semaglutide arm. They did not include participants who dropped out in their final analyses which is a big methodological flaw. I could go on about their choice in and measurement of outcomes, but suffice to say with only 14 participants these results should be taken with a grain of salt.
Further, they did extensive molecular biological studies in mice. There have been MANY (dozens) of murine (mouse) studies showing beneficial effects of various compounds / interventions on mouse knee osteoarthritis. None of them have translated into a therapy for the human disease. Mice live 2-3 years and have very different knee biomechanics than humans.
Appreciate the authors investigative efforts, but more confirmatory studies are needed before I'll be injecting semaglutide into my knee.
The "pilot study" the authors performed was an n=20 with 30% dropout, meaning 14 finished the study, 6/10 in the non-semaglutide arm and 8/10 in the semaglutide arm. They did not include participants who dropped out in their final analyses which is a big methodological flaw. I could go on about their choice in and measurement of outcomes, but suffice to say with only 14 participants these results should be taken with a grain of salt.
Further, they did extensive molecular biological studies in mice. There have been MANY (dozens) of murine (mouse) studies showing beneficial effects of various compounds / interventions on mouse knee osteoarthritis. None of them have translated into a therapy for the human disease. Mice live 2-3 years and have very different knee biomechanics than humans.
Appreciate the authors investigative efforts, but more confirmatory studies are needed before I'll be injecting semaglutide into my knee.
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