Hacker News new | past | comments | ask | show | jobs | submit | reddickulous's comments login

I didn't even know he was sick.


I don't see how it's relevant. The counterfeit adderall being sold isn't pharmaceutical grade meth. People buying black market sealed bottles of adderall would probably want to know that it's likely not adderall.


I think it's relevant because to me the article isn't actually about Adderall vs meth, just using that as the framing for a story about why they think it's bad for anything pharma-related to happen out from under the watchful eye of a US-like medical-industrial-congressional complex.

The author is preying upon readers' cultural understanding of meth (via the news media and shows like Breaking Bad) as something inherently dirty, something for which there is no possible safe usage. The existence of FDA-approved meth ruins the framing even if FDA-grade is not what a buyer would be getting.


I'm a biochemist and I completely disagree with your take.

There are very few situations where prescribing methamphetamine is reasonable. It's a niche drug. Even XR formulations of Adderall are considered a blunt instrument compared to more recent alternatives.

The issue is one of trust, integrity, and safety. Pharmacies should not operate like drug dealers.


Did you mean IR formulations, or are you saying that extended release formulations of Adderall are considered a blunt instrument? Compared to what other than Vyvanse?


IR (instant release) is the opposite of XR (extended release). I said and meant XR. I don’t even think IR should be used anymore, except maybe in super niche situations (I’m not even sure if I can think of any situation where it makes much sense… maybe narcolepsy?).

XR is obviously preferable to IR, but amphetamines have been falling out of favour over the years (it’s a slow trend). Vyvanse, NSRIs and even SSRIs tend to be regarded more and more favourably compared to amphetamines (Adderall) and methylphenidate (Ritalin).

(Disclaimer: I myself take Adderall XR 10mg as prescribed, so I have the opposite of a conflict of interest in this context.)


> The existence of FDA-approved meth...

... changes nothing. If you don't expect to be getting meth, you shouldn't be getting meth.


It would be cool if there was a platform to crowd source compute resources to train stuff like this so that regular people (without 7 figure budgets) can have access to these models which are becoming increasingly out of reach to the general public.


Here is a recent paper (disclaimer: I am the first author) named "Learning@home" which proposes something along these lines. Basically, we develop a system that allows you to train a network with thousands of "experts" distributed across hundreds or more of consumer-grade PCs. You don't have to fit 700GB of parameters on a single machine and there is significantly less network delay as for synchronous model parallel training. The only thing you sacrifice is the guarantee that all the batches will be processed by all required experts.

You can read it on ArXiv https://arxiv.org/abs/2002.04013v1 or browse the code here: https://github.com/learning-at-home/hivemind. It's not ready for widespread use yet, but the core functionality is stable and you can see what features we are working on now.


I agree and it's interesting that he also went on to become a black belt in jiu jitsu which is mostly not bullshido.


Very true - even blue belts in BJJ are savage killers compared to similarly-ranked adherents in other arts, TMA or not, much less the average drunk bully in a bar.

Yet a lot of the same life lessons are passed on through the right, uh, professor.


This could be really useful in VR.


It's a lot easier to hire someone to drive a box truck than it is to hire someone to drive your Kia.


Are government subsidies actually a good way to promote R&D? The U.S. has a couple notable failures there (ethanol/corn, and Solyndra).

And Germany has put billions and billions of Euros into their aggressive renewable energy push with very little to show for it.

https://m.spiegel.de/international/germany/german-failure-on...


Just bought it. Anybody that can build a successful search engine on perl probably has something useful to say. :)

If you want to increase sales you should get some reviews up there on Amazon. If you have a mailing list you can offer a limited number of free private ebooks to beta readers and encourage recipients to leave an honest review. That's standard practice on Amazon. The only stipulation is the review has to be voluntary and honest. Ideally you'd already have that in place on launch day but it's not too late.


A transactional schema usually isn't ideal for running analytics on. So you create a data warehouse that transforms your data into a schema that's more amenable to reporting. They probably have a ton of marketing data also they integrate into the data warehouse to run analysis on.


How can they make money delivering for $9.99? I guess the item prices are jacked up a little.


Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: