My deepest condolences. I will have a lumbar puncture done in a few hours and am facing a diagnosis that could be extremely grave, but everywhere I look there are stories of people who have had it harder. I will keep you and your wife in mind today, and I hope you find peace.
I am running the smaller models in near real-time on a 3rd gen i7, with good results even using my terrible built-in laptop mic from a distance. The medium and large models are impressively accurate for technical language.
I'm using Whisper to transcribe notes I record with a lavalier mic during my bike rides (wind is no problem), but am using OpenAI's service. When it was released I tested it on a Ryzen 5950x and it was too slow and memory hungry for my taste. Using large was necessary for that use case (also, I'm recording in German).