Maybe an evolutionary / structuralist lens is helpful here: terms that rapidly diffuse through discourse are those that people like most, and most people like to anthropomorphize, so "hallucination" has come to take on a new meaning, and we all (to different degrees) know what it is referring to.
What guarantees do services like egg freezing provide, e.g. if the power goes out for their -80 freezer, or if they go bankrupt? What happens to your cells? What about with this service?
Some kind of “failure bond” where the company puts up a security in case of failure might be an option.
Most cryobanks don’t seem like they’d have this problem, but when you move into the decades timescale, things like catastrophic dewar failure can drain the coolant from your samples in minutes, and if it’s not staffed 24/7 with staff trained in contingencies like this (how do you safely remove samples from the dewar fast enough and how do you even know the failure occurred fast enough?) then damage can set in. There may even not be any records made or kept of the failure.
Something to think about if you want to move forward. However, if all you want is epi-DNA, I imagine corpses a few centuries old may qualify as enough. Eggs and sperm need to stay alive and viable, which is a far higher bar.
This is a good point. In general, you get redundancy by splitting samples over multiple locations and storing cells at -196 liquid nitrogen or slightly warmer vapor phase.
I also think sequencing is another form of insurance that applies to cell storage for aging, because sequencing as much of your cells as possible now is basically a digital save state of your youngest cells. A rubric for age-reversal, at least for your cells.
With the news that Apple and OpenAI are closing / just closed a deal for iOS 18, it's easy to speculate we might be hearing about that exciting new model at WWDC...
Ed Tong’s recent release, An Immense World, is an exploration of the unique sensory worlds of creatures throughout the animal kingdom. I enjoyed listening to it while my sensory world was confined to a car.
I think Qualcomm's strength in cellular is what's killing them in laptops. Force-bundling a 5G modem with a weak CPU results in unbalanced laptops that are too expensive for their performance.
They did, but late 2023 is still a very short timeframe (less than 3 years) to get a custom arm64 CPU architecture, ready to ship.
Pre armv8, Qualcomm had strong custom cores, but Krait (their armv8 custom implementation) didn't exactly perform well compared to basic Cortexes from ARM (a problem that wasn't unique to Qualcomm, to be fair), and Qualcomm moved to using those generic ARM cores on most of their lineup.
Qualcomm reportedly did get some TMSC volume at 5/6nm that would correspond to that timeframe, but the timing would be extremely optimistic considering how long of a lead time you need, even if the Nuvia acquisition solved all their problems.
Slight correction: Krait was the name for the excellent ARMv7 core design. The underwhelming ARMv8 replacement was named Kryo. Confusingly, they (at least for a while) kept the Kryo branding even after they switched to lightly-customized versions of cores designed by ARM.
The renaming part btw was quite awful of them, they had a hard time acknowledging that they went back to Cortex based cores and I remember their press release trying to imply they didn't.
They were quite hammering the fact they had a custom arch pre v8, and the turnaround was difficult for them to admit.
Qualcomm modem license is relatively expensive for a laptop. I suspect that, once Apple is ready to launch their own modem, they will include that in their laptops, too.
It disconnects whenever the laptop enters sleep mode, it causes the phone to run very hot and consume lots of battery and, yes, it requires manual intervention before it can be used.
I agree that overall these are probably small issues, but built-in mobile network access would have usability benefits
With a MacBook internal modem would you then have to purchase another 5G plan and a sim or pay extra for including that in your phone plan? I would imagine it’s not cheap
In my country there are plans that allow for multiple additional devices to be linked to an account.
I wouldn’t have to pay anything extra for a 5G MacBook.
Which of course makes total sense technically. Because for my mobile operator there’s no difference (bandwidth wise. And given the packet switched nature of LTE and later, that’s all that matters) whether I’m tethering or connecting multiple devices.
On Android tethering can be enabled with just a few taps.
I wonder whether this could be automated, e.g. you click on the macOS toolbar and a macOS app communicates with an Android app and the apps do the needed actions in the respective operating systems (enable tethering on Android, connect to the WiFi network from macOS).
On the other hand, from a user's perspective only one SIM card and data allotment is needed. I much prefer two devices that I would own anyway over two SIM cards with (in most cases) separate monthly subscriptions or data packs.
People won't stop buying phones because their laptops are 5G enabled. The laptop's eSIM would be on the same plan as the phone. It would help carriers to push more expensive plans with much bigger data caps, which is easy with 5G. To the point of eating some home broadband market share- I imagine some people canceling their home broadband like they've cancelled their phone landlines, which initially seemed unthinkable.
Qualcomm charges you a device price tax for each modem you install in a device. So Apple is understandably uninterested in paying Qualcomm that much. When Apple moves to its own modems, expect to see them appear in Macbooks.
Commercial customers in the field. But this is also a market segment with basically zero Mac users. And small enough of a market that it's way off Apple's radar.
As someone with a spotty internet connection and who likes to work at coffee shops with annoying login prompts, I'd really appreciate a product like that. I can get a data-only sim from Google Fi for free so it'd be an easy purchase for me.
(I have no idea why my internet connection is so bad. I pay for 20Mb/s, and half the time it's like 200Mb/s and the other half I don't have internet at all.)
As with COVID-related outcomes, focusing only on fatalities ignores other meaningful negative outcomes.
Based on personal experience after living SF/Oakland ~ 10 years, I'd also take measurements like "in pedestrian cross-walk" with a grain of salt.
Anecdotally, 1st-degree friends have been involved in:
* Pedestrian killed by a MUNI bus, intoxicated and just out of the cross-walk, the bus driver deemed not at fault.
* Cyclist killed by a delivery truck, while biking in a bike line on Folsom.
* Cyclist in bike lane on Valencia hit by a truck, dealing with TBI and anxiety years later but with no visible damage.
* My Uber driver, turning left onto Valencia, hit a pedestrian holding a red cup. A police officer happened to witness the incident, saw the red cup, and sent the driver on their way in under a minute.
This is the first published IV-administration of a gene-editing CRISPR payload. Interesting convergence with the nanoparticles used in mRNA vaccines. Sickle-cell and immune reprogramming edits have been made on cells removed from the body. Josiah Zayner infamously injected himself with CRISPR at a conference years back, but (1) unpublished, AFAIK and (2) he had been drinking which likely attenuated the payload [and (3) he wanted bigger muscles, not to treat a disease]
Thinking of the encoded genetic information developing over time as simply "training" the neural network of the brain doesn't quite capture development; proteins are manufactured and move in space as the brain is growing in space over time.
It sort of feels like training a neural network is like rewiring an adult brain which has already fully grown. Are there neural architectures which grow over time, or "age", emulating the early development of the brain?
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