This is incredibly true. I've been making a flash game recently, and it's my first, but I've just been overwhelmed with how many images are required.
At every step I'm realizing, "Oh damn, I need images for this. Finds my graphics buddy"
It really is a labor of love, best advice really is do as little organic / moving items as possible. They can be added later without feeling the need of "Oh my god not another batch!"