I don't know that there's a consensus on what the limit really is. Semaglutide is good for about 15%, tirzepatide about 20%, and retatrutide about 25%. Some people don't get that much, some people get a lot more. Personally, tirzepatide got me just over 35%. I never got anywhere near max dose, either, I am what is colloquially referred to as a super responder.
Super responders unite, I'm down 32% and shooting for 36% before I hit maintenance. I only made it about half way up the dosage chart before I had to back off due to losing too rapidly (!!). I took a 3 month maintenance and am back to losing again, it's been life changing.
The other wild thing is general health improvement - all of my bloodwork has gone from questionable to better than standard - closer to ideal values than I would ever expect. Liver values, cholesterol, lipids, blood pressure, everything. I expected them to improve but not to the degree that they have, my LDL has gone down by 60%. Actuarial tables say it's given me another ~10 years of probable lifespan, and even more if you think in healthspan.
Congratulations! It feels great, doesn't it? I was not quite pre-diabetic, but trending in that direction. Blood pressure elevated (but not quite 'high'), cholesterol and stuff in the sketchy zone. But now ... everything is really good! A1C was 4.9 at my most recent test. Cholesterol great, blood pressure ~115/70 every day now, etc. I went from what felt like a slow but steady decline through middle age and now I feel 20 years younger, the future looks not like decrepitude but way more active and exciting.
1. I feel wonderful. Things that were hard are now easy, exercise is invigorating instead of exhausting.
2. I have not. Considered it, but locally the scans are expensive and I could not convince myself what I'd do differently if I knew the numbers. My goals would stay the same.
3. I lift weights, but there's no way around it, losing a lot of weight means caloric deficit and I have definitely lost some mass. I'm trying to establish a slight caloric surplus now combined with a heavier focus on lifting-for-growth to see if I can claw back some of what I've lost. I got big enough at my largest (and I am just over 50 years old, which does not help) that now I have a little bit of loose skin on my belly, thighs, and upper arms ... I'm hoping that if I can regain some muscle that I can alleviate much of that. Otherwise I'll get a surgeon to do it.
4. Currently at 25.2. Could lose some more, but happy enough where I'm at and my test results are spectacular now, so I am no longer targeting further weight loss. I still weigh myself but I am now refocusing my definition for success in how I look and feel.
I also lost 35% body mass, from 318-208 today. It took from September 2024 to beginning of January 2026.
1) amazing, I can actually do things now. I didn’t realize how much I was resting and just not doing anything around the house. I managed to do my work with stimulants but that’s about it.
2) I did a scan and am currently around 110% for with 100% being the baseline for the average male my age, for my muscle mass. I did lose more muscle mass in the 230-210 loss than most of the previous, but I think that’s because I couldn’t ride my bike everywhere as it’s winter time. I had to chug protein shakes while losing weight and do physical therapy for a few body parts, especially my hip and my shoulders as they were easy to hurt. Going to the gym regularly solved this long term.
3) I guess I answered question 2
4) I’m now 27.1 BMI, although my percent body fat is only 18.9%, so I’m not concerned about the number since I have access to a body scanner and can see I’m fine. My visceral fat levels have dropped below concerning levels, which is great.
I also sleep way better, and the heartburn I thought was just a part of life went from “literally every day” to “once or twice a year, and only if I do something I shouldn’t have”.
I was also way more aggressive about just going to the dose and hit 15mg in April of 2025, and have stayed there. I might go for another 10 pounds mostly out of vanity.
> the heartburn I thought was just a part of life went from “literally every day” to “once or twice a year, and only if I do something I shouldn’t have”.
I feel this, too. I was on Prilosec indefinitely, gastroenterologist said I have a mild hiatal hernia and that I'll probably be stuck on PPIs forever. But after losing a lot of weight, I was able to switch to occasional Pepcid instead, with Prilosec temporarily if I get tolerant to the Pepcid. The hernia won't heal itself, but taking the pressure off has really reduced the GERD symptoms.
Not the original guy, but down 32%, for a point of comparison:
1) Amazing, like being a decade and a half younger
2) Not before, planning one in the next couple months, but I use skinfold and impedance and they say I've dropped from about 48% to ~20% as I've dropped from 272 to 186, lean mass seems maybe 5kg lower than I started with? Less lean mass loss than I expected.
3) Weight bearing exercise and medium-high protein intake (>80g/d)
4) Per above, starting BMI 37.9 -> ending BMI 25.9
Your stats are very similar. I started at something like 274 (though my overall highest point ever was 284 a couple years ago) and now I'm down to 181. It's a huge difference, as you say it's like being 15-20 years younger. Life changing.
To add my own anecdata, it took me a bit over a year (September 2024 to December 2025) to lose the weight. I averaged about 1.5 pounds a week consistently.
As you lose weight, your body needs fewer calories to run. That “needed amount” keeps dropping with your size, until it eventually equals what you’re eating on the medication. At that point you’re no longer in a deficit, so weight loss slows or stops.
That is true but requires some extra assumptions to explain why people don't keep losing weight - because the strongest influence on most people's appetite in the short run is how much of a deficit or surplus they're currently in. Thus as TDEE drops, so does hunger.
In "setpoint theory" there's an additional hunger drive based on whether you are below or above a given level of adiposity - your "setpoint". This is often given as an explanation for why people can't keep weight off, and is the sort of thing you'd need to posit to explain why people on GLP-1 inhibitors can't as easily get to lower levels of adiposity.
With the visual analysis of LLMs, throw in some extra ingredients with a camera, microphone, speaker, and display, and were getting close. Add Bluetooth for biosensors and... Iterate a couple of generations...
"The 160 MFLOPS Cray-1 was succeeded in 1982 by the 800 MFLOPS Cray X-MP, the first Cray multi-processing computer. In 1985, the very advanced Cray-2, capable of 1.9 GFLOPS peak performance
...
By comparison, the processor in a typical 2013 smart device, such as a Google Nexus 10 or HTC One, performs at roughly 1 GFLOPS,[6] while the A13 processor in a 2019 iPhone 11 performs at 154.9 GFLOPS,[7] a mark supercomputers succeeding the Cray-1 would not reach until 1994."
These flops are not the same. The 2013 phone flops are fp32, the A13 flops look to be fp32 as well (not entirely sure), while the Cray numbers (like the rest of the HPC industry) are fp64 (Cray 1 predates what would become IEEE 754 binary64 though, so not same exact arithmetic but similar in dynamic range and precision).
A modern Nvidia GB200 only does about 40 tflop/s in fp64 for instance. You can emulate higher precision/dynamic range arithmetic with multiple passes and manipulations of lower precision/dynamic range arithmetic but without an insane number of instructions it won't meet all the IEEE 754 guarantees for instance.
Certainly if Nvidia wanted to dedicate much more chip area to fp64 they could get a lot higher, but fp64 FMA units alone would be likely >30 times larger than their fp16 cousins and probably 100s of times larger than fp4 versions.
Oh but we had The Forbin Project, its sequel Colossus, and later Wargames. Not to mention Star Trek episodes with malignant computers. And I have No Mouth But I Must Scream.
In the 70s, science fiction fed me Cold War fears of world-controlling mainframes.
Colossus: The Forbin Project is simply a renamed release of The Forbin Project, a few months after the later had a poor opening. Didn’t help the box office much. I liked it, back when it was easy to dismiss as an impossible dystopia.
Some anecdotal knowledge I can share on why they used to say wait as long as you can for a hip replacement:
We were told this was because it used to be that they could only do the hip replacement surgery once, and the replacement joint would only last around 20 years max.
So basically it had to be for the expected life span of the patient!
But now this is no longer true. Well, in Australia at least with access to modern replacement parts, surgical techniques and specialists!
I could be muddling it up a bit, so happy to be corrected :-)
I recently got told something similar in Europe, and anecdotally anyone who’d had a hip replacement and waited on it regretted not doing it as soon as the doc told them.
"To connect the UniFi Travel Router to a guest network, open the UniFi Mobile App and select a nearby wireless network. If the network has a captive portal, it will automatically forward to your mobile device for login."
It likely relies on the travel router cloning the MAC address of your phone or whatever you use to authenticate. That way the hotel just thinks the travel router is your phone.
Took my PS5 Pro on a work trip. Was livid to find out the horrific 'browser' on the PS5 wasn't able to handle the captive portal login page. $700 gaming rig and it can't load a simple HTML page so I can enter my name and room number?! Ridiculous.
Thought about it for a few minutes and realized that the portal was likely just doing mac filtering. So I adjusted my MacBook Pro's MAC address to be the same as the PS5, went through the portal login and then powered down the MBP. Booted up the PS5 and I was online.
The issue with OneDrive is that it doesn’t store metadata like the photo location, its damn near useless. But I do pay for storage for Google Photos and iCloud.
If you take all of your photos from your phone, you don’t need your Mac at all. Google Photos will sync directly.
I wouldn’t use BackBlaze (the $7 a month service). It doesn’t support NAS at all and it has to phone home every 30 days or it will erase anything that is stored on external drive.
I would use an app that backs up to their B2 service.
I personally just use my personal AWS account to back up my Plex media and just use the AWS s3 sync command using the AWS CLI and store everything in S3 Deep Archive. It’s less than $2 a month for 2TB.
Also, to be clear, I’m saying to install One Drive and Google Photos on your iPhone.
My approach to this is based around having the least amount of things to manage.
In my scenario, I’m looking for the most simple out of the box systems to backing up that don’t require any self hosted solutions or NAS management and so on.
Just throw money at it!
Hence my suggestion to get a Mac, say a Mac Mini, with a decent sized drive and just sync everything to it.
Fully sync so it downloads the lot and need off loads.
The backup the internal drive with Backblaze.
I appreciate this advice isn’t for everyone, and it may not be the best solution.
But it’s a way to a least have some ultimate disaster recovery in place!
It may not be the cheapest, and cheapest doesn’t mean best. It may not be the best by some other measure of features, but it works and requires zero knowledge and additional hardware.
At least with some kind of backup, everything is not lost!
You don’t have to manage it or think about it. The services will sync for years without intervention until you upgrade your devices. For most people, that’s the important factor in having multi backups of their photos and documents!
I think we are saying almost the same thing. I have iCloud storage, pay for one Google storage and have Office365. I use all three.
But, we travel a lot, it’s a hobby of ours. Being able to see on a map where the pictures were taken is important. iCloud Drive and Google Drive preserve all of that information and the accompanying Live Photos, and depth information. One Drive doesn’t.
But I’m okay with a two full Fidelity sources and one low Fidelity backup.
Having location data is very desirable, and searching my library without it would be painful!
I'm also a huge fan of how iCloud and Google Photos can search my photos just by a description. (not sure if One Drive can, never tried).
I'm horrified when I talk to people who only have their photos on their phones, with no additional iCloud storage. They have no additional backup at all.
Backblaze doesn’t erase after 30 days… I’ve had a computer be offline from it for several months and it still retained all data. And you can use the backblaze docker container to run on a NAS, much much much cheaper than B2.
Wasabi is much cheaper than AWS as well.
Finally the best solution for backing up your iCloud Photos is definitely Immich. Set it up on your own NAS or a VPS, back up to that, and then back up that server to an S3 storage using rsync or restic. I’ll note that I still backup to Backblaze because its so dang cheap.
I spent months trying to find the best setup a few months ago and this is by far the cheapest.
But still, this shouldn’t be required for normal people. They should get what they pay for.
> It has to phone home every 30 days or it will erase anything that is stored on an external drive
It’s actually more nuanced. It will back up files on a USB attached drive. If it doesn’t see the drive attached for 30 days, it will erase the backup.
If you have your computer off for more than 30 days and you bring your computer back on and the USB drive isn’t attached when it connects to BackBlaze, it will erase it.
Only if you’re backing up nothing and using non-encrypted files and making sure you don’t delete anything (rsync with delete turned off). I tested this not even three months ago. I hit $30 with only 3 tb of data with deep archive while wasabi AND backblaze cost less than that. No need to even trust a single provider. If you’re never changing your files AND you don’t care about encrypting them then yes GDA is fine and pretty cheap. Otherwise wasabi and backblaze get more done for less cost.
I understood what you meant about GDA. It just doesn’t come out to that unless you put stuff in and never touch it, which is a valid use case! Don’t get me wrong, I planned on doing the same but with restic it would cost so so much more than wasabi and backblaze that it was a massive waste of money and really revealed amazon’s strategy, which is lock your data away and charge you to access it.
I wasn’t talking about B2 though, I was talking about Backblaze personal, which you can run on a NAS with a docker container.
The cheapest slowest egress, bulk retrieval is $2.56 per terrabyte.
Glacier is meant for in case of emergency break glass. You would use lifecycle policies on S3 to go from fast/more expensive storage for like the first 90 days and then have it automatically go to Glacier.
Yes I know it’s more complicated and nuanced. I’m purposefully yada yada yada’ing
There’s been rumors of Apple working on M-chips that have the GPU and CPU as discrete chiplets. The original rumor said this would happen with the M5 Pro, so it’s potentially on the roadmap.
Theoretically they could farm out the GPU to another company but it seems like they’re set on owning all of the hardware designs.
TSMC has a new tech that allows seamless integration of mini chiplets, i.e. you can add as many CPU/GPU cores in mini chiplets as you wish and glue them seamlessly together, at least in theory. The rumor is that TSMC had some issues with it which is why M5P and M5M are delayed.
For anyone thats been around for more than one hype cycle, this is not a surprise.
Apple clearly takes a 'Measure Twice, Cut Once' approach.
It seems to me that tech and business analysts mostly supply uninformed nonsense opinions around whatever the popular rhetoric of the day is to generate more clicks :-/
How many times do we have to listen to tech and business analysts talking about lacklustre iPhone releases and how Apple hasn't done anything interesting since the original iPhone? But yet the iPhone 17 is flying off the shelves in China.
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