On the contrary. The outer shell/skin of any live aerobic organism is most exposed to oxidative stress (21% O compared to cells inside the body -3%) hence the anti-oxidant defenses are most expressed exactly there. They are also most exposed to solar radiation ("sun-kissed") which makes perfect sense when you review the most active antioxidants -dark-green leafy veggies and dark-colored berries (anthocyanin). Calorie Restriction works by inducing NO (AMPK) and lowering core body temperature thus reducing the inflammatory impact of exogenous agents- nutrients,viruses,environmental stressors etc and also by reducing the endogenous thermogenic hormones (insulin, leptin, estrogen,norepinephrine etc.
