I foresee regulation changes where a pilot of a commercial aircraft requiring multiple pilots cannot be left alone at the controls. Humans can be entirely unpredictable
You have to have one pilot able to take over solo if the other becomes incapacitated (heart attack, food poisoning, whatever). But that means that one pilot can take over by incapacitating the other. There's no way around it (other than, perhaps, three people in the cockpit).
