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This is an interesting conjecture. It could be a cunning Microsoft competitive strategy.

They convince cost-sensitive IT infrastructure groups in other businesses to use Teams by offering it for free, reducing company productivity massively, hobbling product development.

Meanwhile, Microsoft adopt some other pay messaging/video service internally, accelerate product development 10x, become insanely competitive in a whole host of new markets rapidly.


Yes, I use an Onyx Note Air 2 for this purpose. It works nicely, much easier on the eyes than a laptop/Ipad. The Note Air 2 is fairly big - 10.3" - works well for books.


Illumina


They are talking about one 'reference genome'. The variation from human-to-human is relatively small (a few million bases out of 3 billion). The reference genome has historically been some kind of average/mosaic of several individuals (this has obvious disadvantages), good enough to put reads in the right place (mostly), and call 'variants' - the differences that make the test genome unique.

The latest/greatest end-to-end T2T reference is entirely based on 'HG002' an individual from Utah, due partly to new information derived from long read technologies.


Actually the level of variation per genome relative to a reference is still not completely known because we do not have more than a handful of truly complete assemblies. It is clear though that it is much higher than a few million base pairs, perhaps as high as tens of millions, depending on your alignment parameters. Most of the differences are in regions we have not been able to sequence and assemble until the past few years. This paper being a key example. If two males have different versions of large repetitive arrays on the Y then they will already be much more than "a few million" base pairs different


Siddhartha Mukherjee's books 'The Gene', 'Emperor of all Maladies', 'The Song of the Cell' all mix biology and history with lots of detail and are easy to read.


Thanks, will try them out.


The UK has had an industrial intervention policy for ages. Its undeclared but it basically involves supporting finance, real estate, business services and insurance in London above all other stakeholders in the country.


The BBC has some good history ones: In our Time, You're dead to me


The Ted Chiang books are great. Short stories. 'Arrival' the movie is based on one of them.


Liquid biopsy for early cancer detection.


It's not a documentary but the BBC drama 'Micro Men' is very good and AFAIK mostly historically accurate.

It's about the battle between Clive Sinclair (of Sinclair Spectrum fame) and Chris Curry (founder of Acorn Computers, the progenitor of ARM) for dominance in the 80's UK home computer market.

https://www.youtube.com/watch?v=XXBxV6-zamM https://www.bbc.co.uk/programmes/b00n5b92


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