We have no cure now but that may change and depend on early detection just as taking meds now can slow the onset. I don’t want to know makes no sense to me. You would plan your whole life differently and it would actually be quite liberating once you’d come to terms with it.
Rooibos is not tea in the strict sense of the word, it’s a completely different plant with a different set of bioactive alkaloids.
”The MeOH extract exhibited significant inhibition of the major human CYP450 isozymes (CYP3A4, CYP1A2, CYP2D6, CYP2C9, and CYP2C19). The strongest inhibition was observed by the extract for CYP3A4 (IC50 1.7 ± 0.1 μg/mL) followed by CYP2C19 (IC50 4.0 ± 0.3 μg/mL). Among the tested phytochemicals, the most potent inhibitors were isovitexin on CYP3A4 (IC50 3.4 ± 0.2 μM), vitexin on CYP2C9 (IC50 8.0 ± 0.2 μM), and thermopsoside on CYP2C19 (IC50 9.5 ± 0.2 μM). The two major, structurally related compounds aspalathin and nothofagin exhibited a moderate pregnane-X receptor (PXR) activation, which was associated with increased mRNA expression of CYP3A4 and CYP1A2, respectively. These results indicate that a high intake of nutraceuticals containing rooibos extracts may pose a risk of herb–drug interactions when consumed concomitantly with clinical drugs that are substrates of CYP enzymes.”
You need a mix of price, availability and trust. I just head for the nearest Sainsbury’s. They have. Reputation to protect, I can do my shopping at the same time and their prices are competitive. I just wouldn’t go to the cheapest place unless it was a hire car.
I read that people just allow Claude Code free rein but after using it for a few months and seeing what it does I wonder how much of that is in front of users. CC is incredible as much as it is frustrating and a lot of what it churns out is utter rubbish.
I also keep seeing that writing more detailed specs is the answer and retorts from those saying we’re back to waterfall.
That isn’t true. I think more of the iteration has moved to the spec. Writing the code is so quick now so can make spec changes you wouldn’t dare before.
You also need gates like tests and you need very regular commits.
I’m gradually moving towards more detailed specs in the form of use cases and scenarios along with solid tests and a constantly tuned agent file + guidelines.
Through this I’m slowly moving back to letting Claude lose on implementation knowing I can do scan of the git diffs versus dealing with a thousand ask before edits and slowing things down.
It can definitely feel like that right now but I think a big part of that is us learning to harness it. That’s why resources like this are so valuable. There’s always going to be pain at the start.
I've seen this "we're still learning" argument for at least 6 months now and I get it and even agree with it. However at which point do we start to question how much is it part of a learning curve and how much is just limitations of the models/software?
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