Instead of a registry hack (that SmartKeys does), I use Ctrl2Cap - http://technet.microsoft.com/en-us/sysinternals/bb897578.asp.... I used to do the registry hack manually, but remember (although not specifically anymore) there were some issues with it not working at certain times or in certain programs.
I don't use emacs anymore, but still find that C-x, C-c, C-v, and C-anything is easier with this setup.
Windows users, use SmartKeys[1] to redefine CAPS LOCK to Left Control.
I makes the frequent use of the control combinations a lot more bearable.
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[1] http://www.randyrants.com/2008/12/sharpkeys_30.html