Skype doesn't make it easy to use two accounts. There is no "multiple accounts" feature where you can be logged in as one or both; instead, you have to log out and log back in again as the other. Sometimes, you might be on-call, so chatting with friends is OK, but you still need to be available to coworkers.
The problem with Skype is that it's totally closed. I use a multi-protocol IM client, with multiple accounts, so I can chat with people over AIM, FB, Google Chat, my work chat, and so on. Sadly, despite the fact that my work has Google Apps, which includes chat, they have standardized on Skype instead, so I need to have an entirely separate client, and log out and log back in when switching between work and personal accounts.
The problem with Skype is that it's totally closed. I use a multi-protocol IM client, with multiple accounts, so I can chat with people over AIM, FB, Google Chat, my work chat, and so on. Sadly, despite the fact that my work has Google Apps, which includes chat, they have standardized on Skype instead, so I need to have an entirely separate client, and log out and log back in when switching between work and personal accounts.