I think it should work with anything that functions as a disk device in the system. The program itself likely doesn't do much guessing about sector sizes and such, and just uses smaller and smaller read blocks where larger ones can't be read.
It also doesn't know anything about file systems, simply dumping the disk as an image. After that you work with the image, mounting it, rummaging in it with data-restoring tools, or writing to another disk. This minimizes the chance that the original disk kicks the bucket while you're in the middle of the restoration process, or at least the damage from such misfortune.
