It's "the answer to life, the universe, and everything", a result arrived at after a mind-bogglingly powerful computer thought for millennia. After revealing this result, it was soon discovered that the answer only made sense if one knew the question - which no one did. (If I'm recalling correctly.)
But now we know the question is "what is pi perent of leet, rounded to the nearest integer?"
No, it's "the answer to the ultimate question of" life, the universe, and everything. Also, the question is "What do you get when you multiply six by nine?" (so the answer's wrong anyway)