HiCharts has dynamically loadable data. I have a database that has 120M points. I just keep some pre aggregated data to populate the wide periods. As you zoom it it selects smaller aggregation sets. (Think; 1 month for 10 years, 2 weeks for 1 year, etc). If you have the data you only need about 20 lines of JS so support this with json.
That said, bokeh requires little to no javascript and that's a huge advantage if you need to get multiple visualizations. It does, pretty much stock, what you can do with HiCharts without needing as much full-stack expertise.
