App support is forcing me. My iPhone 7 still does everything I need, but 3rd party developers have stopped supporting it. I don't mind if I stop getting updates, but some of these developers are blocking my use of existing apps with a full-screen modal, telling me I need to buy a new phone in order to continue using the app (FlightAware, for example). Perfectly good phone, probably going into the landfill, for no reason other than to appease app developers too lazy to retain already-working code for older devices.
The 7 is coming up on it's 8th birthday, on the bright side that's a pretty good run.
Is FlightAware blocking use of the app now? I assume it's because they've dropped support for iOS 15 (which can be a hassle depending on new APIs they want to use), not the 7 device specifically.
Yea, they likely want to move on from iOS15, which is fine[1]. But at least let existing users with the existing iOS15-working app keep using that app version. But no, instead, they issued a final "update" which does nothing but block iOS15 users with a full screen modal that you cannot skip (as far as I can tell). Totally overboard. I hope this doesn't start a trend.
1: I don't see what the big deal is to just put if statements around any iOS16-requiring new features, yet keep targeting iOS15. We did this all the time back when I used to write iOS apps.
Not a new trend. Many places I’ve worked at (whose business models center around iOS apps) routinely plan to drop old iOS versions, yearly, as the new ones come out.
It gets increasingly more expensive to support older and older iOS versions. These “new features” you’re talking about wrapping in if statements aren’t here and there. Many upgrades are pervasive, and would eventually make every file a branching mess.
Now, you could argue that that should still be the chosen route. I can empathize with that. I like software that just keeps working forever.
At the very least, when they stop releasing updates supporting older OS versions, they should at least leave the old apps already installed on the old devices alone to continue to work. I wouldn’t mind if I never get an app update again, but don’t send a final “update” that disabled the app and tells me to buy a new phone.
Agreed. There should be a warning to those that will be left behind soon, instructing them not to upgrade if they don’t plan on updating, or can’t update iOS.
Usually these salts remain chemically stable for longer periods of time. In the case of alkaloids, they become protonated (here LSD-with-a-proton, a positively charged particle; the tartrate being the negative counterion) and as such are thus less susceptible to oxidation. Can't steal negative charge from something that doesn't have it.
And with LSD freebase that's not an unnecessary luxury, as it isn't the most stable against decomposition. To answer the question... probably this is the most stable formulation to get it into a pharmacy? I guess like you say, not blatantly calling it LSD helps image building too.
With vyvanse, that's actually something else: not a salt but an amino acid covalently bound to amphetamine. This gives a much stronger bond than between tartrate and lsd ions in the salt, one that can be hydrolysed slowly in the gut to produce the active drug. LSD tartrate doesn't have a similar slow release property.
The API in Vyvanase isn't a salt of straight amphetamine though. It has a covalent bond to a group that your body/metabolism needs to (I guess enzymatically) break down to release the amphetamine. More of a prodrug.
No, Sandoz produced LSD tartarate back in the '50s. It's the common salt form of LSD. The freebase is lipophilic, and is typically dissolved in ethanol, while the salt form is water-soluble, and can be soaked into blotter paper or sublingual tablets.
Not sure why this is downvoted, since this has been a working legal loophole for decades. For example, 1cP-LSD is completely unscheduled in the US right now, despite breaking down into pure LSD once consumed (at only slightly reduced potency). It's already banned in several other countries though.
Though, I am sure prescription drugs will always be legal with a prescription, assuming the prescription itself is legal. Even if this were counted as the Schedule I drug LSD that can't be prescribed, it'll probably get moved to Schedule II or III before any actual prescriptions are given out. So anyone who ever gets such a prescription in-hand will always be safe.
I'm generally in favor of letting (healthy) adults decide what they consume (in particular hallucinogens), but I'm not sure it is a good idea to just hand them out to people with real psychiatric disorders without any therapeutic guidance.
I wouldn't even hand it to normal, "stable" people without some guidance. Not everyone handles losing their marbles with grace and aplomb. It's not in the average person's skillset to be able to say, "it's just the drugs" and keep their cool.
One of the other reasons not to give it out freely is that it varies wildly in effect depending on who exactly takes it. I certainly don't lose my marbles when I'm on it, but plenty of people have lost their sanity from it, sometimes for months, years or even life. Not to mention HPPD can sometimes appear, ranging from just "weird" all the way to distressing or madness-inducing.
I'm very eager for a consumer version of Ramp where I can issue myself a card per-subscription service. Then I can review all the cards I've issued, and turn them off if I no longer want the service.
I'm not sure. Can we define alien spores as an agent with intent? Perhaps the sun can be viewed as an agent with intent since it displays an inherent ability to influence the solar system. The universe is swimming in alien interactions.
Precedent | Senior Engineer | San Francisco / Bay Area | Full time
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