Toxo comes into the picture by way of an old wives' tale forbidding mothers from having cats around during pregnancy. Basically the only spot that toxo can reproduce itself is within a cat's stomach. The toxo then goes out with the feces (which is where the caution comes from) and rodents eat the feces. Toxo's mission is to get that rodent back into the stomach of a cat.
Rodents themselves are genetically wired to fear cats. A rat that smells cat urine will go the other way. However, get that same rodent infected with toxo and it will suddenly be attracted to the scent. Thus it checks out cat urine and becomes more likely to find itself in the stomach of a cat.
So you'd think toxo is wreaking havoc with all sorts of elements within the rat, turning it into a deranged rat. Nope. Everything else remains and functions normally - olfaction, social behavior, learning and memory, and even fear behaviors all stay the same.
It takes about 6 weeks for toxo to migrate from the gut to the brain. In the brain it forms cysts in multiple locations, but mainly in the amygdala region. The amygdala is the brain's center for fear and anxiety. It is also the brain center for forming predator aversion pathways. Once in the amygdala toxo is able to take dendritic nerve cell endings and cause them to shrivel up.
Shrivel up the dendritic spine, shrivel up the fear pathway.
Taking the creepiness up several notches, recall that other fear/anxiety based behaviors remain constant. The parasite is actually locating and unwiring the very pathway it needs to destroy.
Amazingly, it does not stop there. Toxo wants to make cat urine attractive and it is able to do so by hijacking another well known pathway; sexual attraction. Part of the neural connection for sexual activity passes through the amygdala. This gets rewired and a rodent infected with toxo will no longer have a fear response to the urine but it will have activation of this sexual response pathway, resulting in attraction to the scent.
Eau de merde. C'est fantastique!
They are mapping out the toxo genome. One curious element discovered is that this protozoan parasite has two genes for tyrosine hydroxylase. This is responsible in part for the production of dopamine, which is all about rewards and the anticipation of rewards (really it's the thing that gets you to do the thing needed for the reward). It acts as a catalyst in the conversion of L-tyrosine into L-DOPA, which is in turn a precursor for dopamine.
So at the right moment, the parasite secretes the enzyme, thus driving the neurons to create dopamine at the time the toxo wants them to, thus associating dopamine with the neural pathway that toxo wants used!
Do other parasites that are closely related to toxo share this gene? No. Strangely it does not have genes for other common hormones - just this one that allows it to plug into the key for mammalian reward systems. And it starts generating it after it has penetrated into the brain and formed cysts, especially cysts in the amygdala.
For humans the current clinical dogma is that it's a disaster for a fetus but otherwise runs its course and goes latent. However, a small literature exists suggesting that males in particular become more impulsive after a toxo infection and that people who are toxo infected are 3-4 times more likely to be killed in car accidents that involve reckless speeding.
He quips that this is a protozoan parasite that knows more about the neurobiology of fear and motivation than 25,000 neuroscientists standing on each others' shoulders.
And it's not alone. The rabies virus knows how to control the neurobiology of aggression. It makes the animal more likely to bite and pass on the rabies infection.
I would say that this one of the greatest casualties in the war on doping, Dr Ferrari especially has amassed a wealth of knowledge on blood and human energy systems that will never be acknowledged.
https://en.wikipedia.org/wiki/Michele_Ferrari
I used to give cancellara the benefit of the doubt. But after discovering the very very sneaky second bike change I think its very unlikely he didnt do mechanical doping.
Cancellara had a mechanical issue and did a first bike chance. The main mechanic jumps out of the car and gives him a new bike. A few km's later Breschel has a real issue and requests a new bike, but the main mechanic isnt in the car anymore resulting in Breschel getting the wrong bike, losing a lot of time and never returning to the front. A few km further the images show Cancellara suddenly sitting on his original bike.
What happened, at the point where cancellara did his first bike change, the stage makes a loop. The mechanic had to walk 500 meter to get on the other part of the stage. What does amateur footage reveal. In a turn everybody where makes the short turn, Cancellara goes wide where the main mechanic is waiting with the original bike and you see Cancellara do a lightning bike swap.
Its a sad thing but after all these years I am convinced Cancellara cheated.
“His thighs were measured with a circumference of 73 centimetres (29 in). A circumference of 86 centimetres (34 in) has also been recorded, and the size of his quad muscles has led to him being called "Quadzilla" by some in his sport.”
