23andMe can't possibly run independent replication studies of every genetic link they want to report on. Nor should they have to, any more than your doctor should have to personally run a study replication in order to inform you about the results of your blood test.
You're just repeating the original argument, and it wasn't a good argument the first time.
First, 23andMe isn't working in the realm of established science -- most of this stuff is highly speculative, at best. Blood tests are not speculative precisely because they're regulated by the process that you're arguing 23andMe should be able to ignore.
Second, the "your doctor shouldn't have to run the study" argument is the reddest of herrings. Your doctor doesn't have to do that (anymore...) because the regulatory system has provided a network of providers who do it more reliably.
Third, your doctor really does have to know how to interpret the results of your blood test. She can do that because the science is well-established, and the results are directly correlated to certain clinical outcomes. For most of this genetic testing, there's no equivalent interpretation. That's why you need genetic counselors, who know enough to know when an association study is total garbage. Or if a "50% change in risk" is meaningless in a larger context.
In short, it isn't especially onerous to want 23andMe to report only those genetic variations that are based on clinically relevant data, for which their tests are accurate and precise. That's just the basic standard for medical testing.
I started using one of these this year, and it's working well, but not in the way I expected.
I expected that: the light would wake me up, and it would be nicer than an alarm.
In actuality: I wake up often in the early morning anyway, and normally I roll over and go to sleep. If I happen to wake up in the 20 minutes when the light is rising, I don't go back to sleep, I just get up instead.
Result: the light isn't "waking me up", but I awaken "naturally" most days because of the light anyway.
Yep. For all its faults, that book has changed my life. For the sole reason that it convinced me to try slow-carb dieting. That led to reading more about low-carb diets, and from there to (so far) sustainable weight loss.