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Interesting and thorough article, very good read.

I've posted about some of the interesting stuff going on regarding stem cells, particularly around hockey legend Gordie Howe's rather miraculous recover from a stroke earlier this year. I'm really not sure why this isn't getting more news nationally, or even why on HN it isn't getting any traction/discussion:

http://www.freep.com/story/sports/nhl/red-wings/2015/05/18/g...


https://news.ycombinator.com/item?id=9566335

That's my original post yesterday for this story. No discussion or interest/upvote.

So is it simply that the average HN'er is around 28 years old and just doesn't care about aging or stem cell research that is mostly aimed at fixing 'old people'? Is everyone just assuming this stuff will get sorted out in the next 20 years by time the average HN'er actually needs to worry about it?

Or is it because the stem cell medical centers that provided Mr. Howe with the treatments are outside the US? Aka, not invented here so must be BS?

It's puzzling, I mean we all have parents that are aging and having gone through watching a parent lose a lot of their capabilities from a stroke last year (and eventually dying from the strokes fallout a few months later), all I can say is this stuff can become front and center to your personal interest very rapidly when it hits home.


"That's my original post yesterday for this story. No discussion or interest/upvote."

The surface area of HN is so broad, the number of readers interested in pretty low. This is a observable problem. I often see lots of votes and zero responses for interesting posts.

Interesting enough to click, glance over, but not enough to think about and comment.


I was really hoping Dark Souls was one of his examples. The game incorporates its own take on death/mortality in a way that no other game touches upon. It's also brutally hard and death is actually expected part of the experience; often you can't get past an area without dying first and in a few sequence, you have to die to advance the story.

In Dark Souls, you are dead. Undead. That's the story. When your character is defeated, your essence goes back to the checkpoint because of a magic doodad (that no-one remembers (or manually uses the item, for that matter)).

While in terms of playing a video game that's all nonsense - you have a character, it runs around doing things until it 'dies', so we talk of being defeated as "I died" - in Dark Souls you don't "die", and that's a fundamental part of the story. It's why you are where you are, why the things you fight are where they are. Why some things you fight disappear in a puff of magic smoke, and other things leave corpses. You can temporarily 'become human' in Dark Souls, but that's really just an improved link to the human essence - you don't actually 'return to life'. It really is a beautifully subtle and complex game with it's underlying backstory.


It's impressive, no doubt, but I wonder about the actual utility of the device.

My main concerned is the 20m battery life/record time - that is pretty limiting. If I were to use this to record myself snowboarding (like the video shows), that would be a problem. Here in Colorado a typical blue rated mountain run is easily 20m from top to bottom, esp. if you aren't gunning it the whole way. When I ride alone I can maybe go top to bottom in slightly under 20m but I'm flying and really pushing it the whole time, I wonder if the drone could even keep up in that situation (speed would be over 25mph almost the entire time).

Pretty cool but I personally think there is much bigger market for a device designed to record kids playing hockey, basketball, soccer etc... imagine a tripod that tracks your kid, that would be way way more killer and useful for most people and probably a ton cheaper as you could use a smartphone as the camera.

Technically it's impressive as hell, I just don't know about how practical is in actual use.


There is a tripod that automatically tracks you. I get ads for it on YouTube all the time. http://www.gizmag.com/soloshot-automated-tripod/25453/

I haven't been able to figure out how these work. GPS alone wouldn't give the resolution and responsiveness required. It doesn't seem to be CV-based either, since there's often no line of sight of the tracking device. Perhaps the tripod has two directional signal strength sensors so it can tell if the beacon is to the left or right, and move in order to keep the beacon centered.

The popular theory is that it's a RTK differential GPS system: base station in the tripod transmitting correction information to the remote unit. The explains the warmup time, the accuracy, as well as the big price tag.

http://electronics.stackexchange.com/questions/73083/how-doe...


This was my question on Stack Exchange! I was so angry because I was so curious how this worked, but I was downvoted to hell.

Ha! I found your question a couple months ago after youtube hit me with the soloshot ad, and I couldn't figure out how it worked. Despite being downvoted, it still ranks fairly high on the SERP for "how the hell does the soloshot work, their site is useless".

I guess Stack Exchange isn't the place for discussion, just question and answers only

I have no clue why you got downvoted, but then again, I fail to understand the Stack Exchange system and community in general.

This is by requirement line of sight. So indeed a cheap radio frequency tracker should be able to do the job. There are just minor issues with multipath and transmitter power.

EDIT: The included antenna is a wifi-like omnidirectional antenna, so I guess it's just using GPS. The precision is greatly improved due to large distances (linear precision is amplified into angular precision by O(distance) )


Thanks, that's an awesome product, never seen this before! Very cool.

More info here: http://shop.soloshot.com/


A bigger issue to me is what do you do with Lily after it has run out of battery. I don't think I want to carry it for the rest of the day on the ski fields, mountain biking, trail running or anything else, it is fairly cumbersome. And I wonder how tough it is when it is in a back pack and I fall and land on it.

Very cool device and it would have a lot of practical uses, but not sure it will ever be that useful for the masses.


"When I ride alone I can maybe go top to bottom in slightly under 20m but I'm flying and really pushing it the whole time, I wonder if the drone could even keep up in that situation (speed would be over 25mph almost the entire time)."

Where do you ski? 20 min at 25 mph implies an 8.3 mile long run.


My rock climbing friends and I have been watching the drone market. 20m in rock climbing just wont cut it at all :\

That 25 mph is not all horizontal, and any downward movement would mean less power drain from the drone. Though I'd definitely agree that the battery life is a pretty big problem.

I'm sure they will also sell a Lily branded external battery that can be kept in your backpack and used to recharge it.


Maybe, but the FAQ states the current battery isn't replaceable. So it seems more likely they'd have to come out with an entire new unit in order to have external batteries.

It doesn't seem like something they're interested in for the launch.


Since they're using the upfront pre-order money to cover manufacturing costs, I would bet enough feedback from customers (or even speculative customers) asking for a 30 min minimum would have enough impact for them to source different batteries or reduce weight. Features like this can make or break a flashy new product like Lily.

Removable batteries would likely also hamper the ruggedness (IP67 rating).

A bigger issue is that drone power consumption goes down as they go faster. Even if 20m at 25MPH is fine, you'll actually get less than that if you go slower. Hovering uses a lot of power.

Multicopters have this time limitation in general. They don't have great flight times due to the power density of the batteries. It's the main limiter of the platforms really.

I had to read your post several times that by 'm' you meant minutes. Without that it makes the Colorado ski resorts seem a little less impressive.

20 minutes should be plenty for skiing, and should cover more than one descent in most cases.

The airspace is going to be pretty hilarious at Killington on a weekends if half the people with GoPros upgrade to drones.


Stuffing webpages into a WebView and then selling it on the App Store has been standard fair for years (PhoneGap popularized this method 4+ years ago now).

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This is pretty awesome. Hopefully they figure out a way to allow me to write my mods in C#, that would just sweeten the deal that much more (I know Minecraft is a Java app, just saying that would be a cool feature if they can work that out).

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This project of mine may interest you: https://github.com/SirCmpwn/TrueCraft

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I'm excited. How far along is it?

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Check out the blog: http://truecraft.io

It's got:

- Multiplayer support

- Entities (items, sand, gravel)

- World and player data persistence

- Crafting

- Farming

- Procedural terrain generation

About 10% of the world logic (i.e. the movement of water, growth of plants, behavior of doors) is implemented. Notably missing: mobs, combat, redstone, smelting.

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Thanks, very helpful.

I'm not sure I would have any inventory, the idea is pretty specialized and I would be selling it to a limited number of large institutions.

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The best play, IMO, is to sell the company within the provisional period.

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Needs a legend; I'm not sure what a few of the little icons represent.

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In the infographic section entitled Active Repositories, from left to right:

    Javascript
    Java
    Ruby
    Cascading Style Sheets
    Python
    PHP
    C
    C++
    C#
    Shell Script (bash et al)
    Objective C
    Go language
    perl
    Puppet
    GNU R

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I resolved the second to last one by this method: https://www.google.com/search?tbs=sbi:AMhZZisSnBBfayiYq1eLbO...

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Now if only Meteor would support this all would be good in the world.

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+1

RethinkDB's realtime capabilities would fit perfectly with Meteor.

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How? Meteor's server-side architecture is still oriented around polling the DB, and I believe that's because many apps are still explicit request-response oriented.

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As @imslavko said, when using Meteor with MongoDB (which I believe is the only production ready DB driver) it observes the oplog [1] for changes. You can use the polling observer too though.

You can find out more about the LiveUpdate core project of Meteor on their site [2] - it basically says the implementation of Live Updates for each db driver is independent to what the db is capable of. Specific mention of RethinkDB and Firebase is made as DBs that are built with making realtime data something that you get for relatively little work.

[1] https://github.com/meteor/meteor/blob/devel/packages/mongo/o...

[2] https://www.meteor.com/livequery

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No, Meteor's server-side architecture uses MongoDB's replication log that is analyzed to get updates.

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Philip K Dick - VALIS, Divine Invasion and (next) Transmigration of Timothy Archer.

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Or it's more profound, positive effects on mood.

My wife takes fish-oil daily as a mood stabilizer. When she skips a day or two all hell breaks lose in our house. Hell I take a smaller dose myself and it's amazing how much better I am at keeping my mood in check; I've never had much trouble but I have always gotten little edgy when hungry. That doesn't happen anymore.

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It is nearly impossible to be objective about your own brain. If you suspect X makes you happier, then it probably will. After it works once, you will probably believe X makes you happier, and if definitely will.

In other words, even if fish-oil does work as a mood stabilizer, there would be no way for you, as a consumer of fish oil, to be even slightly certain it works.

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I used to play a trick on myself where I'd hold a particular hand position and meditate on a state of mind, one intended to clear my mind and get centered, the other to get me amped up to go do some work. (I worked in construction at the time) It worked amazingly well, and I spent several weeks / months feeling no other emotions. I'd feel the state slipping, and just hold the hand position and the state would come back. Only reason I stopped was that the emotional monotony got old after awhile.

I have no trouble believing that fish oil as a mood stabilizer can work fantastically, and yet have no physiological effect whatsoever.

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You can look at double blind trials of the effects of fish oil as a mood stabilizer. Its possible that the GP's wife has an idiosyncratic lack of reaction and is just fooling herself but that would be pretty improbably so I'd say her beliefs are well justified. The observed effects aren't small, we're talking about things like reducing assaults in prison by 1/3.

http://bjp.rcpsych.org/content/bjprcpsych/181/1/22.full.pdf

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This is interesting, but 1) it does not test the effects of fish oil as a mood stabilizer and 2) there is something sketchy about the way the data are reported.

1) It is a study of vitamin, mineral and essential oil supplements. There is no basis for ascribing any measured effect to essential oils as such.

2) In a number-rich report, it's odd that they don't report either the number or distribution of incidents in any detail, and I can't make their averages work out.

For example, they have 172 people in the study for an average of 142 days, and they talk about numbers like 11 and 16 incidents per thousand person-days, which would lead one to predict around 170x140x(11 to 16)/1000 ~ 250 - 300 incidents, but they then go on to talk about studying 754 Governor and minor reports, or 338 Governor reports and 416 minor reports (in all cases the reports appear to cover the full study population, which is the majority of the prison population).

One can conclude from this that most of the incidents in the prison are due to the people who weren't in the study, maybe? I don't know, but there's something odd going on.

Furthermore, they don't given any idea of individual variation within the population. The conclusion you'd draw if most of the incidents are associated with a few individuals vs spread out across the population might not be the same. Were all individuals pretty much similar in their response, or was the effect localized to some? The results as reported are consistent with a few problematic individuals becoming peaceful and everyone else getting slightly worse.

When making an argument that an intervention is good for a population, you really have to dig into the support for the claim across the population, not report averages as if they could only arise one way.

So while this is intriguing an interesting, it isn't as strongly convincing as one would like.

What I'd like to see (and would have insisted on as a reviewer) is a table showing the raw numbers of minor and Governor's reports issued on each population over the study period, and at least histograms showing the number of individuals in each populations with N Governor's and M minor reports against them, which would allow one to judge the distribution of incidents in the population.

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>It is nearly impossible to be objective about your own brain.

People can't trust their own perceptions? Isn't that what gaslighting is about? Why do we accept eye-witness testimony in court cases if people should not trust their own perceptions?

If a person saw another person strike another person, should we trust their testimony? No! We should have a double-blind placebo controlled experiment where we go back in time and have a large sample size of identical people watching the same person getting struck and not struck in alternate universes and ask them if the person was struck to determine if their perceptions can be trusted.

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Eye-witness testimony is mostly bunk and is often not trusted in court. It's been shown over and over that eye-witnesses can be manipulated (even without their knowledge) and are not reliable.

No, you can't trust your own perceptions. You can only really trust that you are having a perception at this moment in time.

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At some point I had to take medication where one of the known side effects where higher blood pressure.

I also noticed a significantly increased blood pressure every time I took this medicine.

This continued until one day someone knocked the door just before I took my pills, and I still got the same symptoms while the pills where safely on the kitchen.

I then realised my brain had played games with me and since then the side effects disappeared.

...and I consider myself somewhat rational.

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> When she skips a day or two all hell breaks lose in our house.

Only a "day or two?" Sounds like the placebo effect. Try swapping her fish oil capsules for something else and see if there is any difference.

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I wonder if the mood stabilization effect has anything to do with blood sugar levels?

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>My wife takes fish-oil daily as a mood stabilizer.

This is why I take it as well. Its incredible how well it works. I hate to engage in conspiratorial thinking, but some of these overly critical analysis really seem to be coming from a big pharma "tell them the shit doesn't work" perspective. In a country with for-profit medicine, non-patented or low-profit treatments often get demonized. Especially by "useful idiots" who follow this ultra skeptical mindset where only what they hear from an authority like the government or academia, has any real value. They refuse to believe these institutions can have institutional fraud, incompetence, groupthink, or unfair motivators to getting published. As someone who works in a healthcare related field, its pretty obvious that industry controls the narrative, at least to me.

Or can be gamed by private industry and other benefactors who have a bias or agenda.

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Dietary supplements are, if anything, not low profit.

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Indeed. To close the loop, for those who don't see it: the companies that make "dietary supplements" have all the same incentives that Big Pharma does.

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And I've taken it daily, in sufficient quantities, for several months at a time, without noticing any difference at all.

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Did you consider quality as well as quantity?

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Yes, I compared brands and didn't buy cheap stuff.

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