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Some things take 1 second on 1 machine beefy machine or 6 hours on a cluster due to latency issues. And yes I do mean 20,000 times slower, though 2,000 is far more common due to latency inside a datacenter being around ~500,000 ns vs ~100 ns for main memory vs 0.5 nm from L1 cache.

PS: Not that most systems are built around these kinds of edge cases, but 'just use a cluster' is often not a good option unless each node is sufficiently beefy.

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