If you could do the same job on a fleet of 8-16GB servers.. you can get a lot more CPU for a lot less dollars. Depends if you really need everything on 1 machine or not (as of course nothing will beat same machine in memory locality)
softlayer, dual Xeon 2000 Series: 512GB, $1,823.00/mo (3.56 $/gb/mo)
these are on-demand prices. pre-pay, or use a term discount, and its cheaper.
Build it yourself: You can build a Dell or similar on a 2-Xeon-proc (E5 series), your main limit is getting good prices on 16x 32GB DIMMS. But lets say you can buy the RAM for ~$6500, then its just dependent on the rest of your kit, lets say $10,000 flat for the whole server. $277.77/mo over 36 months, but you still need network infrastructure, and you might want a new one in 12 months, but you get the general idea.
 - http://www.rackspace.com/en-us/cloud/servers/onmetal