It also happens that the same basic financial strategy one might employ whilst making $30,000/yr applies whilst making $300,000/yr. That is, spend less than you earn.
Or to put it a little more brazenly:
Debt to gross income metric? You fucking make $300,000/yr! Why on Earth do you need to be borrowing money? So you can afford to live in the bay area? So you can "put it all on black" investing in something-or-other? I'm not saying you're wrong to do it, but for Christ's sake don't complain about not having enough opportunity. Your problem isn't your leverage, it's your stupidity.
Spend less than you earn!
If your $300K/yr job is in the Bay area, and you like the job and area, it seems eminently reasonable to borrow money to buy a house there.