I have used Python under IntelliJ IDEA and find it unbearably slow. I am not sure if Pycharm would be faster than IntelliJ IDEA.
Spyder2 is great, except that I have had it crash several times. The deal-breaker has been debugging support. When I hit "step into function" on the current line, it runs out of the current function. And there is no call-stack.
PTVS (Windows-only) seems to be fast enough. In some cases though I see exceptions showing up in the console window that are not reflected in the IDE, leading to confusion. Hope they fix this.
Another benefit of using an Eclipse IDE is the wide array of plugins for other languages. I have a Perl plugin and SQL plugin. I like being able to use the same IDE when I do need to switch languages, which is so far what has put me off trying Pycharm or Wing.
I'm running PyCharm (3.1 pro) and I currently have plugins for .sh, .pl, .md, and more. Some plugins require download (iirc, I had to go through a wizard to get the plugin for markdown)
It's low risk trying PyCharm. The community edition is fairly full-featured, and is free.