If you look at the reviews you'll get a better understanding.
The wikipedia talk page is interesting.
Here's my personal story about how I conquered my RSI: stopped using Emacs. It helped that I moved from a developer to a sysadmin role.
When I do occasionally use Emacs, it's with viper mode.
* ergo-emacs key bindings (http://ergoemacs.org/features.html)
* auto-completion (e.g. binding dabbrev-expand to an easy reachable key/combo)
* put window/buffer navigation onto easier reachable keys (for me F7, F11 work well)
* Make buffer switching smarter by using ido-switch-buffer and ido-find-file instead of the normal switch-buffer and find-file functions (see documentation for ido-mode)
* desktop-save-mode so you don't have to repeatedly re-open files after restarting emacs
* Using auto-generated boilerplate when creating new files (see Emacs manual for define-auto-insert and friends)
* using a Kinesis Advantage keyboard helps with emacs key combos as Ctrl/Alt can be reached via the thumbs without moving the hands.